维胺酸阻断宫颈癌癌前病变发展的研究

AStody on Chemoprevention of Retinamide II from Cervical Precancerous Lesions

按随机双盲设安慰剂方法，使用维胺酸栓剂对宫颈癌癌前病变患者进行阻断性治疗，每日１栓，宫颈局部用，５０次为一疗程，共两疗程。近期癌前病变消失率为６８．５７％，总有效率为７４．２９％；远期疗效，与激光、电熨两法相比较，疗效近似（统计学上差异尤显著意义），而与一般妇科常用消炎药物相比，差异具有非常显著的意义，且方法简易，效果明显，适用于我国宫颈癌的高危人群，可作为我国宫颈癌高发区防治宫颈癌的主要措施。

he patients with cervical precancerous lesions were double─blindly randomized into two groups.The one was treated with retinamide II (RII) suppository intravaginally and the other with placebo,onee daily for 50 days as a course. The results showed precancerous lesions in 68.57% of the patientsdisappeare, with an overall effective rate of 74.29 % after two-course treatment with RII.Itslong─term curative effect approximated to that with laser beam radiation and electrocautery(P>0.05),and differed significantly(P<0.01) from that with common antiphlogistic. So, RIl can be used as a ma-jor measure in prevention and treatment for cervical cancer in high─incidence areas in our country.