摘要
用控制硒、镉含量的饲料喂养生长期SD大鼠,观察低硒和高镉对大鼠心肌的损伤作用。结果表明:低硒和高镉可引起大鼠心肌的灶状坏死,对心肌和心肌膜系统均有不同程度的损伤作用,心肌的谷胱甘肽过氧化物酶和细胞色素氧化酶的活性下降。提示克山病区粮中存在损伤大鼠心肌的因素,补硒可防止病区粮所致的心肌损伤。
he effects of low-dose selenium and high-dose cadmium on myocardial injury were studied in weanling S.D. rats fed with feed containing controlled levels of selenium and cadmium. Results indi-cated low-dose selenium and high-dose cadmium could injure heart and myocardial cell membrane sys-tem to a certain extent,and cause focal necrosis and reduction in activities of glutathione peroxidase and cytochrome oxidase of heart muscle in rats.It suggested there were eertain factors in the grain pro-duced in the areas where Keshan disease was prevalent,which imjured heart muscle in rats.So,selenium supplement could prevent from myocardial injury caused by the grain grown in those areas.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1994年第2期94-96,共3页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金
关键词
硒
镉
心肌病
Selenium Cadmium Myocardial diseases