低硒高镉对大鼠心肌损伤作用的研究

Studies on the Effects of Low-dose selenium and High-dose Cadmium on Myocardial Injury

用控制硒、镉含量的饲料喂养生长期ＳＤ大鼠，观察低硒和高镉对大鼠心肌的损伤作用。结果表明：低硒和高镉可引起大鼠心肌的灶状坏死，对心肌和心肌膜系统均有不同程度的损伤作用，心肌的谷胱甘肽过氧化物酶和细胞色素氧化酶的活性下降。提示克山病区粮中存在损伤大鼠心肌的因素，补硒可防止病区粮所致的心肌损伤。

he effects of low-dose selenium and high-dose cadmium on myocardial injury were studied in weanling S.D. rats fed with feed containing controlled levels of selenium and cadmium. Results indi-cated low-dose selenium and high-dose cadmium could injure heart and myocardial cell membrane sys-tem to a certain extent,and cause focal necrosis and reduction in activities of glutathione peroxidase and cytochrome oxidase of heart muscle in rats.It suggested there were eertain factors in the grain pro-duced in the areas where Keshan disease was prevalent,which imjured heart muscle in rats.So,selenium supplement could prevent from myocardial injury caused by the grain grown in those areas.