甲基汞亚致畸量对小鼠脑影响的形态学观察

Morphological Observatlons of Effects on Mouse Brain Exposed to Subteratogenic─dose of methylmercury

我们利用电镜及电子计算机数字化图像系统等方法，对在子宫内接触甲基汞亚致畸量的小鼠脑变化进行了短期及长期研究，并把两个时期的变化做了对比研究。结果表明，短期组和长期组小鼠脑细胞均有变性、脱失；长期组病变重于短期组。显示了甲基汞亚致畸量对小鼠脑的毒性作用具有长期性；由于染甲基汞仔鼠无明显外观及行为异常，因而具有隐匿性。

hort─term and long─term changes in mouse brain caused by in utero exposure to subteratogenic─dose of methylmercury were studied with electronic computer digitalized graphic system,electron microscopy and other methods. Results revealed degeneration and loss of mouse brain cells occurred both in short─term and long─term groups,but the lesions were more severe in the latter than in the former groups.The fact that exposed young mice exhibited no obvious abnonnality in their outward appearance and behavior indicated subteratogenic─dose of methylmercury had a long─term and latent toxic effects on mouse brain.