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重组人白细胞介素-11对小鼠尾部表皮颗粒层形成和血清白细胞介素-2水平的影响 被引量：3

Effects of recombinant human IL-11 on the formation of mouse-tail scale epidermis granular layer and the level of IL-2 in serum
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摘要 目的观察重组人白细胞介素-11(rhIL-11)对小鼠尾部表皮颗粒层生成和血清白细胞介素-2(IL-2)水平的影响。方法采用小鼠尾部鳞片表皮颗粒层形成模型,不同组别的小鼠给予rhIL-11或甲氨喋呤,观察其对鼠尾鳞片表皮颗粒层和血清IL-2含量的影响。结果rhIL-11可显著促进小鼠尾部鳞片表皮颗粒层形成(P<0.01),并显著抑制血清IL-2的水平(P<0.01)。结论rhIL-11可抑制角质细胞增殖分化不全和减少促发因子IL-2的生成,对银屑病具有较好的防治作用。 Purpose To study the therapeutic effects of recombinant human interleukin-11 (rhIL-11) on the formation of mouse-tail epidermis granular layer and the level of IL-2 in serum.Methods The formation of mouse-tail scale epidermis was used as the epidermis parakeratosis model, and different groups of mouse were treated with rhIL-11 or methotrexate. Its action in regulating the formation of mouse-tail epidermis granular layer and the level of IL-2 was observed.Results The rhIL-11 significantly promoted the formation of mouse-tail epidermis granular layer and decreased the level of IL-2 in serum. Conclusion The rhIL-11 has good efficacy in treating animal psoriasis model by inhibiting keratinocyte proliferation and parakeratosis and by decreasing the level of IL-2.
作者 王进 李应全 谢青 王菊英 张岫美
机构地区 山东大学医学院药理学研究所
出处 《中国生化药物杂志》 CAS CSCD 2005年第3期155-157,共3页 Chinese Journal of Biochemical Pharmaceutics
关键词 重组人白细胞介素-11 表皮颗粒层 银屑病 白细胞介素-2 recombinant human interleukin-11 mouse-tail epidermis granular layer psoriasis interleukin-2
分类号 R965 [医药卫生—药理学] R986 [医药卫生—药品]
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参考文献7

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二级参考文献47

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共引文献27

同被引文献30

  • 1刘梅青.紫草提取物对鼠尾角化异常的恢复作用[J].临床皮肤科杂志,2003,32(8):449-450. 被引量：3
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引证文献3

二级引证文献4

中国生化药物杂志
2005年 第3期

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