孕晚期维生素营养状况与胎儿宫内生长迟缓的病例对照研究

Case-control Study on Intrauterine Growth Retardation and Vitamin Nutritional Status in Late Pregnancy

对９７名胎儿宫内生长迟缓（ＩＵＧＲ）孕妇和１３３名对照进行了孕晚期膳食摄入量及血液维生素水平的对比研究，结果发现：ＩＵＧＲ孕妇热能、蛋白质摄入不足，Ｃａ、ＶＢ＿２缺乏，ＶＡ、ＶＢ＿１摄入低下，血清维生素Ｅ含量只有对照组一半（Ｐ＜０．０１）；多元逐步回归分析表明孕母血清维生素Ｅ与婴儿多个出生时生长指标其回归系数为正。红细胞转酮酶活力（ＴＰＰ％）和谷胱甘肽还原酶活性系数（ＡＣ）值两组比较差别无显著性，但均提示两组孕妇有硫胺素及核黄素缺乏（ＴＰＰ％＞１６％，ＡＣ值＞１．２）。

inety-seven cases of pregnant women with intrauterine growth retardation(IUGR)and 133 con-trols were investigated on their dietary intake and blood vitamin levels in late pregnancy.Results showed insufficient calorie and protein intake, deficiency in calcium and vitamin B_2, and low intake of vitamins A and B_1 in pregnant women with IUGR. Their serum level of vitamin E was only half as that in controls(P<0.01).Mothers'serum level of vitamin E correlated positively to several indicators re-flecting infant growth with muItiple stepwise regression analysis. There was no significant difference of activity of erythrocytic transketonas activity(TPP%)and activity coefficient(AC) of glutathione reductase between the two groups. It suggested pregnant women in both groups suffered from deficiency in thiamine and riboflavin (TPP%>16%,AC>1.2)。