^(99)Tc-MDP治疗强直性脊柱炎的疗效观察

Therapeutic effect of ^(99)Tc-MDP in the treatment of ankylosing spondylitis

目的观察99Tc-亚甲基二膦酸盐(MDP)注射液治疗强直性脊柱炎的疗效。方法对83例强直性脊柱炎患者静脉滴注99Tc-MDP,观察治疗前后临床和实验室指标及副作用。结果99Tc-MDP治疗强直性脊柱炎的总有效率为89%,在减轻临床症状,尤其是改善晨僵和关节活动度方面疗效明显,且无明显副作用。结论用99Tc-MDP治疗强直性脊柱炎疗效显著,使用安全。

Objective To observe the therapeutic effect of 99Tc-methylene diphosphonic acid (MDP) in the treatment of ankylosing spondylitis (AS). Methods 83 patients with AS were treated with 99Tc-MDP. Clinical manifestation, laboratory examination before and after treatment and side effect were observed. Results The total effect of this treatment was 89%, and the effectiveness of relieving clinical symptom was significant, especially the morning stiffness and limitation of articulation function. No adverse effects was observed. Conclusion The clinical effect of 99Tc-MDP is obvious, and it is safe and no significant adverse reaction.