摘要
我们采用20%Ⅲ度烧伤大鼠模型,分对照组、平衡盐溶液组和高张盐溶液组。后两组均按Na^+·mmol^(-1)·kg^(-1)/BSA%分别计算伤后24h 液体复苏量。动物均于伤后24h 活杀,分别测定全血粘度、组织含水量,用电镜观察肾小球微循环的变化。实验发现,复苏后组织含水量均增加,平衡盐溶液组尤为明显(P<0.05)。血粘度均明显下降,高渗组尤甚(P<0.01)。电镜发现,对照组肾毛细血管扩张,RBC 凝聚,内皮细胞水肿裂隙增大。平衡盐溶液组微血管通畅。高渗组微循环未见明显改善,微血栓充塞血管腔。我们认为高张盐能改善体循环,但如何进一步改善微循环尚值得深入研究。
Hypertonic saline solution(HS)has been used effectively to treat different kinds of shock.In this experiment,all rats are inflicted with a full-thickness burn of 20% BSA,and they are divided into three groups.Group Ⅰ,control;group Ⅱ,resuscitated with balanced saline solution;group Ⅲ,with HS.All animals are sacrificed at 24 hours postburn to determine blood viscosity(BV)and tissue water content(TWC),as well as to observe the microcirculation in kidney with electronmicroscopy.We find that the TWC increased sig- nificantly in group Ⅱ(P<0.05),while BV decreased,especialy in group Ⅲ(P<0.01). The electronmicroscopic observation indicates that.In group Ⅰ,there are capillary dilatation, red cell aggregation,endothelium edema,and appearance of many gaps between endotheli- urn.In group Ⅱ,the blood flows easily and smoothly.In group Ⅲ,the improvement of micro- .circulation is not significant and the blood vessel is filled with mierothromboli.The results show that HS can improve Systemic circulation,but not microcirculation.
关键词
烧伤
液体复苏
微循环
休克
Burn
Fluid resuscitation
Microcirculation
