摘要
我们将52例烧伤面积30%以上的病人(平均烧伤面积58.4±18.88)按四个时相期(休克、回收、感染、感染后期),进行了尿白蛋白(ALb)、血清和尿β_2-微球蛋白(β_2-m)、免疫球蛋白 G(IgG)、粘蛋白(THP)肾功能放免七项动态系列联检1106次测定,结果提示伤后尿 ALb、IgG、THP、血清和尿β_2-m 均有明显升高,但血清 IgG 下降。通过联检可以对肾功能损伤的部位、范围、程度、鉴别诊断及预后判断提供有价值的资料,并为测定烧伤后肾功能、滤膜通透性及肾小管功能提供了灵敏的指标。
The urine ALb,serum and urine β_2-m,IgG,and THP were serially deter- mined with radioimmunoassay to assess the renal functions during various stages of burn in 52 patients with TBSA over 30% ((?)±s 58.4±18.88%).It was found that the urine levels of ALb,IgG,and THP and the serum and urine levels of β_2-m were remarkably in- creased and that the serum levels of IgG were decreased after burns.Our study suggested that the measurements of urine ALb,serum and urine β_2-m,IgG,and THP using radioim- munoassay were sensitive in assessing renal glomerular permeability and tubular functions after burn.It is presumed that such methods might be used to help identify the location,the extent,and the severity of the renal abnormalities and provide valuable information about the differential diagnosis and the prognosis of the renal damage in patients with extensive burns.
