四君子汤对烧伤豚鼠早期代谢营养的影响

Effects of Chinese herb decoction sizunzituang on metabolism and nutrition in burnt guinea pigs

为探讨四君子汤对烧伤早期代谢营养的作用,采用30%Ⅲ度烧伤豚鼠胃造口模型将400g左右豚鼠分别在喂养等量热卡、氮和自由进食两种膳食条件下,将31只豚鼠分为四组,即喂养治疗组(n=7),喂养对照组(n=4),自食治疗组(n=9),自食对照组(n=11)予以观察。结果发现:自由进食时,四君子汤能增加摄食量,减轻伤后体重丢失,改善氮平衡,增加肝、回肠粘膜含氮量,而躯壳重及腓肠肌含氮量增加不明显,但静息代谢率则增加;等量喂养时,四君子汤治疗组体重、躯壳重及腓肠肌含氮量显著低于对照组,而肝、肠粘膜重量及含氮量差异无显著意义。此外,四君子汤还可调整激素和内脏组织含水量。因此,我们认为四君子汤对改善烧伤后代谢营养及脏器功能可能是有益的。

Sizunzituang is a decoction prepared by boiling water extraction of codonop- sis pilosulae,Acractylodes,poria and glycyrrhiza.Male burnt (30% TBSA) guinea pigs weighting 380～420 grams with a pre-formed gastrostomy were studied.The animals were divided into two groups,both of them were fed with pellet chow.One received sizunzituang, while the other group served as controls.The treated group was found to eat more food,with better nitrogen balance,higher body and ileum mueosal weights,and higher nitrogn contents of the liver and ileum mucosa than control group.However,the body and carcase weights as well as gastrocnemius muscle nitrogen contents in the treated group were reduced signifi- cantly as compared with those in the control group.In addition,Sizunzituang can also regu- late the secretion of hormones and visceral water contents.The above findings indicate that the decoction may be beneficial in improving the metabolism,nutrition,and visceral organ functions after a burn injury.