摘要
目的改进昂丹司琼的合成工艺。方法以1,2,3,9四氢4H咔唑4酮经N甲基化、Mannich反应和缩合得止吐药昂丹司琼。结果取得较佳的工艺条件,总收率为43.9%。结论该方法易于工业化生产。
AIM To improve the syntesis process of Ondansetron.METHODS Antiemetic Ondansetron was synthesized from 1,2,3,9-tetrahydro-4H-carbazol-4-one via N-methylation,Mannich reaction and condensation.RESULTS The suitable conditions were obtained,and the total yield was increased to 43.9%.CONCLUSION The process is practical and easy to popularize in industry.
出处
《江苏药学与临床研究》
2005年第3期15-17,共3页
Jiangsu Pharmacertical and Clinical Research
关键词
昂丹司琼
止吐药
合成
Ondansetron
Antiemetic
Synthesis
