异丙酚复合芬太尼用于人工流产的临床观察

Effects of Propofol Combined with Fentanyl on Induced Abortion

目的观察异丙酚或异丙酚复合芬太尼用于人工流产的临床效果。方法140例早期妊娠妇女随机分成异丙酚组(P组,70例)和异丙酚复合芬太尼组(F组,70例。)P组静注异丙酚2mg/kg诱导。F组静注异丙酚1.5mg/kg前1min先缓慢静注芬太尼1ug/kg。术中静脉追加异丙酚0.5mg/kg。观察记录两组诱导时间、苏醒时间、用药总量、呼吸循环参数改变和不良反应。结果术中异丙酚总用量P组明显高于F组,诱导苏醒时间F组也少于P组。两组呼吸循环抑制发生率无显著差异。结论异丙酚复合小剂量芬太尽用于人工流产可减少异丙酚用量,降低费用,苏醒快,镇痛满意,值得推广应用。

Objective To observe the effects of propofol or propofol combined with fentanyl during induced abortion period. Methods 140 early pregnant women who were scheduled for pregnancy termination were divided into 2 groups:group P(propofol,n=70) and group F(propofol and fentanyl, n=70).The patients were induced with intravenous propofol(2mg.kg-1)in group P. Before propofol(1.5mg.kg-1) induction intravenous fentanyl(1ug.kg- 1) were used in group F. All patients were maintained with bolus of propofol(0.5mg.kg-1) to provide anesthesia during induced abortion. Induction time,recovery time,the dosage of propofol,NBP、HR、SPO2,side effects and anesthesia effect were recorded.Results Patients in group P had more dosage of propofol of induction and had longer recovery procedure than that in group F.But changes in circulatory and respiratory system have no significant differences between these two groups.Conclusion Combination of propofol and a little dosage fentanyl during induced abortion can decrease propofol dosage,reduce cost,more rapid recovery,more satisfied anesthesia.