尿胰蛋白酶原-2、血脂肪酶、血淀粉酶在急性胰腺炎早期诊断中的应用比较

Comparison of Urine Trypsinogen-2,Serum lipase and Serum Amylase in Application of Early Diagnosis of Acute Pancreatitis

目的本实验旨在探讨尿胰蛋白酶原-2、血淀粉酶、血脂肪酶检测对急性胰腺炎的早期诊断意义。方法对70例急性胰腺炎患者、70例非急性胰腺炎患者,70例正常健康体检者测定尿胰蛋白酶原-2,血淀粉酶及血脂肪酶,比较其对诊断胰腺炎的敏感性及特异性。结果尿胰蛋白酶-2诊断急性胰腺炎的敏感性为96.0%;特异性为94.3%,血脂肪酶分别为78.0%、76.0%;血淀粉酶分别为80.0%、80.0%。结论胰蛋白酶原-2较之常规的血淀粉酶、血脂肪酶检测,在急性胰腺炎早期诊断中具有更高的价值。

Objective To compare the clinical significance of detection of urine trypsinogen-2, serum lipase and serum amylase in early diagnosis of acute pancreatitis. Methods In 70 cases of AP patients, 70 cases of non-AP patients and 70 cases of normal volunteer, urine trypsinogen-2, serum lipase and serum amylase were detected ,moreover ,the sensitivity and specificity of three substances were compared. Result The sensitivity and specificity of urine trypsinogen-2 were 96.0% and 94.3%, the sensitivity and specificity of serum lipase were 78.0% and 76.0%, the sensitivity and specificity of serum amylase were 80.0% and 80.0%. Conclusion Compared with conventional detection of serum lipase and serum amylase, detection of urine trypsinogen-2 exhibit more values in early diagnosis of acute pancreatitis.