阿魏酸钠对溃疡性结肠炎患者血小板功能异常的影响

Effect of sodium ferulate on the abnormal function of platelet in patients with ulcerative colitis

目的:探讨阿魏酸钠对溃疡性结肠炎(UC)患者血小板异常功能状态的影响。方法:采用ELISA法,单克隆酶联免疫吸附法及血小板粘附检测仪检测39例活动期及25例缓解期UC患者与30例健康对照者的血小板a颗粒膜蛋白(GMP-140)、血栓烷B2(TXB2)、6-酮-前列腺素F1a(6-Keto-PGF1a)、血小板粘附率及血管性假血友病因子相关抗原(vWF:Ag)水平。结果:患者组血小板活化指标及血管内皮损伤程度显著高于对照组(P<0.01),活动期UC患者又明显高于缓解期UC患者(P<0.05)。阿魏酸钠治疗组治疗前后血小板活化指标、血管内皮损伤指标及临床疗效差异有显著性(P<0.05),而一般治疗组治疗前后差异无显著性(P>0.05)。结论:阿魏酸钠能明显抑制UC患者体内血小板活化,减轻炎症反应,对UC有一定治疗价植。

Objective:To study the effect of sodium ferulate on the abnormal function of platelet in patients with ulcerative colitis(UC).Methods:In64patients with UC and30healthy people,a-granule membrane protein(GMP-140),thromboxane B 2 (TXB 2 ),6-keto-PGF 1a were detected by means of ELISA,platelet adhesion rate was detected by the platelet adhesion tester,von willebrand faetor related antigen(vWF:Ag)was detected by the means of monoclonal-ELISA.Results:The indices of platelet activation and vWF:Ag in patients with UC were signif-icanrly higer than those in the control group(P<0.01).The difference of platelet activation indices,vWF:Ag and clinical effect before and after treatment was singnificant in sodiumferulate therapy group(P<0.05),but the common therapy group did not so.Conclusion:Sodiumferulate can significantly restrain the activation of platelet in UC,relieve the inflammatory reaction and showsome therapeutic effects.