液体复苏加1-6-FDP对严重烧伤家兔心肌功能变化的研究

Myocardial function after fluid resuscitation with addition of 1-6-FDP in severely burned rabbits

采用家兔25％Ⅲ度烫伤模型,分别于伤前、伤后即刻、伤后1、3、5、7 h 测定左心室内压峰值、左心室内压最大变化速率及血浆容量(不测伤后即刻值),并观察了液体复苏加1-6-FDP 对严重烧伤休克期家兔 LVSP、LV±dp/dt max 的影响,结果表明严重烧伤后心肌的收缩性和舒张性均立即受到抑制,并呈进行性减退,单纯的液体复苏并不能明显改善心肌的收缩性和舒张性;单用1-6-FDP 治疗可在伤后一定时间内对心功能有支持作用;而在液体复苏同时给予1-6-FDP 可使心肌的收缩性和舒张性得到明显改善,其与烧伤未治疗组和液体复苏组比较差异有非常显著性意义,提示在液体复苏的同时.应用1-6-FDP,可改善心肌功能,有利于休克的复苏。

An experimental study is designed for the evaluation of the effecf of fluid resuscitation with addition of 1-6FDP on myocardiac function in severely burned rab- bits.60 rabbits were divided into four groups.Group A (n=15) served as control without treatment.The animals in group B (n=15) were treated with 1-6-FDP immediately after burning.The animals in group C (n=15) were treated with balanced saline solution (BSS).The animals in group D (n=15) were treated with BSS plus 1-6-FDP.All rab- bits sustained 25% TBSA full thickness burn.LVSP,LV±dp/dt max and PV were mea- sured before burn,immediately after burn,and 1,3,5,7h,after burn,except that PV was not measured immediately after burn.The results showed that depression in my- ocardial contractility and relaxation were noted immediately after severe burn.Fluid re- suscitation alone did not significantly improve myocardial function (P>0.05 compared with control).The administration of 1-6-FDP showed a beneficial effect in improving myocardial contractility and relaxation within 3 hours postburn.With fluid resuscitation plus 1-6-FDP,myocardial contractility and relaxation were improved statistically signifi- cantly as compared with the control group (P<0.01)