置泵灌注并直肠腔内滴注化疗在不能切除的晚期直肠癌中的应用研究

Chemotherapy of pump-implementation and rectoclysis for advanced unresectable rectal carcinoma

目的探讨置泵灌注并直肠腔内滴注化疗,对不能切除的晚期直肠癌的应用价值。方法将我院1995-2003年住院的32例不能切除的晚期直肠癌分成两组,置泵灌注并直肠腔内滴注化疗组(治疗组)16例,与外周静脉化疗组(对照组)16例,对其疗效进行分析。结果治疗组1、2、3年生存率分别为100%、75%、50%,对照组为75%、56.3%、12.5%。两组各项指标分别比较差异有显著性(P<0.01)。结论置泵灌注并直肠腔内滴注化疗在不能切除的晚期直肠癌中的治疗效果明显优于外周静脉全身化疗组,且痛苦小、经济,是值得推广的治疗方法。

Objective To evaluate the effects of pump-implementation chemotherapy and intrarectal chemotherapy for advanced unresectable rectal carcinoma . Methods 32 cases of advanced unresectable rectal carcinoma were divded into two groups:pump-implementation and intrarectal chemotherapy group (chemotherapy group,16 cases) and peripheral veous chemotherapy group (control group,16 cases).Results In the pump-implementation and intrarectal chemotherapy group ,the 1-,2-,and 3-year surival rates were respectively 100%,75%,50%,compared with 75%,56.3%,12.5% in control group(P<0.01).Conclusion Pump-implementation chemotherapy and intrarectal chemotherapy is superior to peripheral venous chemotherapy in improving survival rates of patients of advanced rectal carcinoma.