摘要
１９例进行期胃癌患者，随机分为静脉营养支持组（７例）、化疗组（６例）和静脉营养支持加化疗组（６例）．术前给予５天静脉营养支持、或化疗、或静脉营养支持加化疗。于治疗前后，经ＦＡＣＳｃａｎ氩离子激光流式细胞仪（ＦＣＭ）测定胃癌细胞和正常胃粘膜细胞ＤＮＡ含量、倍体类型及细胞周期各时相比例，结果发现，肿瘤细胞Ｓ期％、Ｓ＋Ｇ２＋Ｍ期的％在静脉营养支持５天后明显增高（Ｐ分别＜０．００和０．０１）；静脉营养支持加化疗后，显著下降（Ｐ分别＜０．０５和０．０２５）；单纯化疗后无显著改变。各组正常胃粘膜细胞在治疗前后，ＦＣＭ测定结果无显著改变。提示静脉营养支持能刺激胃癌细胞增殖，对正常胃粘膜细胞无明显影响；静脉营养支持能增强胃癌化疗效果。
Abstract The purpose of this study is to elucidate the
effect of preoperative parenteral unutritional support(PNS)plus chemotherapy on tumor cell
kinetics .19 advanced gastric cancer (AGD)patients were di-vided into the following
groups:group A(n=7 ):in addition to their oral intake ,received a PNS for5 days,which yielded
117Kj kg-1.d-1.of non-protein calories and 0.15g.kg-1.d-1 of nitro-gen,Group B (n=6):were infused
with 5-Fu at 8～10mg.kg-1.d-1for 5 days and mitomycinC at 6～8mg.d-1 on the first and fifth day
.Group X(n=6):received a PNS plus 5-Fu with MMC as group A and B did.Specimens of gastric
cancer and normal gastric mucosa were takenendoscopically before and after PNS.All
specimens were studied by flow cytometry for cellcycle analysis .The results showed that the
frequency of cells in S and proliferative phases were significantly increased after PNS (P<0.01,
p<0.001),but decreased after PNS+chemotherapy(p<0.05,p<0.025).No significant change after
single chemotherapy was observed.In conclusion,PNSmight enhance the effect of
chemotherapy in AGC patients,probably by stimulation of tumor cell kine-tics.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第2期137-140,共4页
Chinese Journal of Oncology
