摘要
检测67例食管癌病人手术前、后和22例根治术后随访病人的外周血自然杀伤(NK)细胞数量、血浆肿瘤坏死因子(TNF)及前列腺素E2(PGE2)水平。发现食管癌病人NK细胞数量减少,TNF、PGE2水平升高,与正常对照组相比,差异有非常显著性意义。三项指标水平与肿瘤TNM分期密切相关。根治性肿瘤切除术后,NK细胞数量增多,TNF、PGE2水平下降,与术前相比,差异有显著性意义,但并未恢复至正常水平。肿瘤复发、转移后,NK细胞数量再度减少,血浆TNF、PGE2水平再次升高,而且比临床发现肿瘤复发、转移的时间早2~8个月。此结果表明,动态检测食管癌病人外周血NK细胞数量和血浆TNF、PGE2水平,对判断术后疗效、估计预后、及早发现肿瘤复发和转移有较大价值。
Abstract the number of NKcell in peripheral blood,plasma
levels of TNF and PGE2 were determined in67 patients with esophageal squamous cell
carcinoma of various stages (Ⅱ、Ⅲ、Ⅳ)before and after operation,in 22 postoperative
follow-up patients and in 20 healthy volunteers.The findings showed a significantly decreased
number of NK cells and higher levels of TNF and PGE2 inpatients with cancer compared with the
healthy control subjects (p<0.01).The three parameters were found to be closely related to the
TNM staging of the tumors.The number of circulating NK cellsincreased and the plasma TNF
and PGE2 levels decreased in patients after radical operation after compared with the
preoperative ones,but didn't reach the normal levels.Those whodevelopedtumor recurrence or
metastases had a fall in NK cell number and a rise in the plasmaTNF and OGE2 levels
compared with disease-free patients and normal controls.Moreover,the decreare of NK cell
number and increase of TNF,PGE2 levels occured 2~8 monthw (mean5 momths )before
relapse or metastases eas clinically diagnozed.Additionally ,the NK cell number was found to
be negatively correlated with the plasme TNF,PGE2 levels,and the TNFconcentration positively
corrclated with serum PGE2.We would concllude that determination of num-ber of circulating NK
cells and plasma TNF and PGE2 concentration is of great significance on assessing prognosis
and monitoring early tumor recurreuce or metastasis.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第2期132-136,共5页
Chinese Journal of Oncology