摘要
黄芪有效成分Ｆ３在癌症和艾滋病患者的体外实验研究结果表明：（１）Ｆ３加入５０ｕ／ｍｌ白介素Ⅱ（ｒＩＬ－２），其所诱导的ＬＡＫ细胞对人类黑色素瘤Ｈｓ２９４Ｔ的杀伤率可达的６４％，与单独使用５００ｕ／ｍｌ白介素Ⅱ时的效果（６０％）相似。（２）使用Ｆ３后，患者所需的ＬＡＫ细胞数量可减少一倍。一些对ｒＩＬ－２诱导不敏感患者的ＬＡＫ细胞变得异常敏感。提示：运用生物反应调节剂（ＢＲＭＳ）Ｆ３增强ｒＩＬ－２所诱导的ＬＡＫ细胞杀伤活性达到减毒目的是一个值得探索的方向。
Abstract The in vitro induction of LAK cell activity was studied in
cancer and AIDS patients. F3,animmuno-regulatory component of Astragalus membranaceus
was shown capable of potentiatingthe LAK cell inducing activity of rIL-2.The killing activity
against Hs294T melanoma cell ling ofLAK cells induced by 50 U/ml rIL-2 in the presence of
F3(55μg/ml) reached 64% which wascomparable to that (60%)induced by 500u/ml of rIL-2 alone.
With F3 plus rIL-2,the effector to target cell ratio could be reduced to one-half in order to obtai n
an equivalent level of cytotoxicity when rIL-2 was used alone. In some patients, whose
peripheral blood lymphocytes were relatively inert to rIL-2,F3 could make them responsive to
rIL-2.These results imply that F3 May be useful to potentiate LAK cellactivity, reduce the amount
of rIL-2 and thus minimize the later’s toxic side effects when used in vivo.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第3期167-171,共5页
Chinese Journal of Oncology
