快中子治疗骨肉瘤的观察

FAST NEUTRON TREATMENT OF OSTEOSARCOMA

中国科学院高能物理研究所研制的中国第一台快中子治癌装置，于１９９１年１１月开始用于临床，共治疗骨肉瘤患者１２例。北京医科大学第一医院共治疗５例，其中３例放疗单纯用快中子，另２例放疗用快中子和６０Ｃｏ混合线。中子总剂量为６６０～２１６８ＮｃＧｙ。中子根治治疗剂量为１８００～２１００ＮｃＧｙ，术前放疗为８００～１２００ＮｃＧｙ。大部分患者疼痛缓解或减轻，肿瘤体积有所缩小。病理检查显示，快中子根治量照射有１例全部杀灭局部瘤细胞，４例只达到中度放疗反应；不能全部杀灭局部瘤细胞，且放疗后肢体功能差，放疗后手术治疗是需要的。本组实验设计的根治剂量显然偏高。通过这５例的总结，认为快中子治疗主要适应于手术不能切除的骨肉瘤，照射剂量需进一步调整。

Abstract Twelve patients with advanced osteosarcoma were treated with fast neutron at the Neutron TherapyFacility, the Hight-Energy Physics Institute, Chinese Academy of Science. Of the 12 patients, 5 wereoperated after radiotherapy.Threeof them received fast neutron alone, and the other 2 with added 60Co. The doses ranged from 660 NcGy to 2 168 NcGy.Pain was relived and the tumor sizedecreased in all the treated patients. Only one case was found histologically free of viable tumorcells. Skin reaction was serious and the knee joint function was impaired in all patients.