食管癌家族易感性与免疫功能的研究──有家族史的食管癌患者及其亲属的免疫功能测定

IMMUNOCOMPERENCE OF ESOPHAGEAL CANCER PATIENTS WITH FAMILIAL CANCER HISTORY AND THEIR RELATIVES

对有食管癌家族史的５８例食管癌患者及其２３名一级亲属、２０例其他癌家族史的食管癌患者，进行了细胞免疫功能测定，并以无癌家族史的１１４例食管癌患者及３０例正常人作为对照。结果表明，有癌家族史的患者，其皮肤迟发超敏反应和淋巴细胞转化，明显低于无癌家族史者（Ｐ＜０．０５）；其一级亲属的迟发超敏反应，淋巴细胞转化、ＩＬ－２诱导反应、ＮＫ活性亦明显低于对照组。而且，约２／３的有癌家族史的患者，与其亲属有着类似的免疫缺陷。此结果提示，食管癌的家族易感性可能亦与家族性的免疫缺陷有关。

AbstractCellular immunity was assayed in 58 esophageal cancer patients with family history ofesophageal cancer, 23 patients’First degree relative,20 esophageal patients with family history ofother malignant tumours.114 esophageal cancer patients without cancer family history and 30 normalsubjects were taken as control.The results showed that skin delayed hypersensitivity(DTH)reaction andlymphocyte response to PHA were significantly lower in patients with cancer family history than thosewithout. The DTH reaction,lymphocyte response to PHA and IL-2,NK activity were also remarkavly depressed in their first degree relatives, when compared with normal controls. These reaults indicate thatfamilial immunodeficiency might be one of factors of familial aggregation of esophageal cancer.