伴有颈动脉斑块的高血压患者尿酸检测的意义

The Association Between Serum Uric Acid and Carotid Atherosclerosis in Hypertension Patients

目的探讨高血压患者颈动脉斑块与尿酸及肾功能改变的关系。方法回顾分析151例[男81例,女70例;平均年龄(72.28±9.45)岁]2003年住院高血压患者资料,根据颈动脉多普勒检查有无颈动脉斑块划分为颈动脉斑块组及正常组,分析两组同期住院24h动态血压、心脏超声、血脂及尿酸、肌酐、尿素氮、血糖等结果。结果两组尿酸值分别为(374.6±122.8;317.5±93.0)μmol/L。颈动脉斑块组明显高于颈动脉正常组(P=0.002)。斑块组尿素氮、肌酐明显高于正常组(P=0.005,P=0.017)。24h动态血压平均舒张压及白昼舒张压亦有明显差别。直线相关分析显示,颈动脉斑块与尿酸水平呈正相关(r=0.225,P=0.005)。Logistic逐步回归分析,结果显示自变量尿酸、年龄对颈动脉斑块有影响。结论高血压患者尿酸与颈动脉斑块呈正相关,尿酸水平及年龄影响颈动脉斑块形成。

ObjectiveTo study the relation between carotid atherosclerosis and serum uric acid and the renal function in patients with essential hypertension.MethodsOne hundred fifty one hospitalized patients [male 81 casees, female 70 casees; mean age (72.3±9.5)year] were enrolled and their medical records were analysed retrospectively.Based on the presence of carotid plaque, patients were divided into plaque group(group P, n=105) and without plaque group(group N, n=46).24 hour BP, echocardiography, blood lipids, uric acid, BUN, creatinine and blood sugar were determined and compared between them.ResultsUric acid was significantly higher in group P than in group N [(374.6±122.8 vs 317.5±93.0)μmol/L, P<0.002].Serum creatinine was higher as well [(117.7±89.2 vs 95.7±19.7) μmol/L, P=0.017] .Linear regression showed uric acid was weakly correlated to the occurrence rate of plague(r=0.225, P=0.005).Multiple variables regression analysis indicated that uric acid and age are the 2 determinants for the presence of carotid plaque.ConclusionHigh blood uric acid concentration was associated with carotid plaque.Uric acid and age are the two determinants for the presence of carotid plaque.