摘要
观察硒利生对顺铂毒性和小鼠肿瘤生长的影响,发现硒利生对顺铂致死毒性,肾脏和造血系统毒性均有不同程度保护作用,其效果优于亚硒酸钠和现已证实可诱导金属硫蛋白(MT)合成、降低顺铂毒性的有效药物次硝酸铋。经MT测定结果表明,硒利生的MT诱导作用最强(P<0.01),亚硒酸钠次之。由此证明了诱导体内MT增加是应用微量元素药物解救顺铂引起的重金属中毒的环节之一,但两者均不引起肿瘤中MT升高。体内抑瘤实验和体外细胞毒实验提示,硒利生对肿瘤生长没有促进作用,也不降低顺铂疗效。
Abstract The effects of Lisheng-Se(Seleninized wheat
germ)on metallothionein (MT)induction,lethalsystemic toxicity,nephrotoxicity, hemotoxicity and
anticancer activity of cisplatin (CDDP),were investigated in mice. The systemic toxicity of CDDP
was significantly reduced by preadministration of Lisheng-Se(P<0.05 or P< 0.01).The protective
effects were better than its inorganic form(Na2SeO3)and Bi(BSN),(0.05 < P< 0.1).The MT level in
the liver, kidney,heart and tumor tis-sues of mice treated with one of those compounds was
determined.The results show that the levelsof MT induced by Lisheng- Se were significantly
increased in liver and kidney(P<0.01 andP<0.05).It was just in conformity with the conclusion
that the best protective effect appeared inthe groups treated with Lisheng- Se. These results
suggest that increased MT synthesis in the liverand kidney may be involved in the protective
effects of Lisheng-Se tested on the lethal toxicity,nephrotoxicity and hemotoxicity produced by
CDDP. The experiments also show that Lisheng-Sedid not affect the anticancer activity of CDDP
in viro and in vivo, while the MT level was not in- creased in cancer(P<0.05),so Lisheng-Se
might not only improve the therapeutic index ofCDDP,but also did not cause drug-resistance of
cancer cells.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第4期280-283,共4页
Chinese Journal of Oncology
基金
国家自然科学基金