栓塞化疗在肝癌切除术后的价值

EVALUATION OF CHEMOEMBOLIZATION AS AN ADJUVANT THERAPY FOR PRIMARY LIVER CARCINOMA AFTER SURGICAL RESECTION

为探讨降低肝癌切除术后肝内复发率的方法，从１９８９年１０月至１９９２年１２月，对在院手术切除的２１９例原发性肝癌病人作前瞻性研究，估价术后辅加肝动脉栓塞化疗，对降低术后复发率的疗效。结果表明，根治切除术或姑息性切除后３至４周辅加栓塞化疗，能降低其术后复发率，提高其术后生存率。

Abstract IN order to decrease the intrahepatic recurrence rate after surgical resection of hepatoma,from October 1989 to December 1992,219 patients were recruited to a prospective trial to evaluatetranscatheter hipatic arterial chemo embolization (TCE)as a postoperative adjuvant therapy for pri-mary liver carcinoma.These patients who underwent radical or palliative resection were divided into 3 groups :1) Resection of tumor,(2)TCE three to four weeks after asection;(3)Relapse after resection plus TCE. This study presented the principle,techniques and results of TCE. The intrahepatic recurrence rate was 58.6% in gmup Ⅰ and 9.5% in group Ⅱ(P< 0.001). The 1 ,3 year survival rates were 67.2%, 52.0%, 42.8% of the patients in group Ⅰ, while 95.2%,84.7%,67.7%in the patients in group Ⅱ(P<0.05).The ,2 ,3 year survival rates were21.5%, 0%, 0% of the patients who underwent palliative. resection only,hile 66.7%, 41.7% of the patients in group Ⅲ(P<0.00.Taken together,adjuvaut chemoembolization helps decrease the recurrence rate and increase the surival rate in patients with primary liver cancer treated with surgical resection.