乳腺癌病人血清中谷胱甘肽—S转移酶的研究

CLINICAL STUDIES ON SERUM GLUTATHIONE S-TRANSFERASE LEVEL IN HUMAN BREAST CANCER PATIENTS

首次检测了２２４例女性乳癌，１７例乳腺良性肿瘤和９６名健康女性的血清谷胱甘肽—Ｓ转移酶含量，重点探讨了其和乳腺癌生物学特性的关系。结果表明，乳癌病人血清中总谷胱甘肽—Ｓ转移酶含量为１．２２±１．４４ｎｇ／ｍｌ，阳性率为５１．８％，明显高于良性肿瘤组（１７．７％）和对照组（４．２％）；但是与乳癌肿瘤大小、病期早晚、淋巴结转移数目、雌激素受体状态无明显关系；对预测治疗效果、监测病情、判断预后意义不大。

Abstract The level of serum Glutathioe S-transferase (GSTs)was first measured in 224 female patients with breast cancer and 17 patients with benign breast tumor and 96 normal female subjects. Therelationship between serum GSRs and biological characteristics of breast cancer was studied .The mean serum GSTs in patients with breast cancer was 1.22±1.44ng /ml. The positive rate was 51.8%. The level of serum GSTs in the patients with breast cancer was significantly higher than in normal subjects and patients with benign breast tumor .No correlation was found with regard to the level of serum GSTs, the size of the breast cancer,stage, lymphatic metastasis and estrogen receptor status. Serum GSTs level is thus of little value in the evaluation of response and prognosis of breast cancer.