系统性红斑狼疮患者尿视黄醇结合蛋白的检测及其临床意义

Determination of urine Retinol Binding Protein and its clinical in Patients with Systemic Lupus Erythematosus

目的了解系统性红斑狼疮患者肾小管受累情况。方法应用双抗体夹心酶联免疫法(ELISA)检测33例系统性红斑狼疮患者(SLE组)及30例正常人尿视黄醇结合蛋白(RBP)含量。结果SLE组尿RBP含量明显高于正常对照组(P<0.01),且活动期组(26例)尿RBP含量高于静止期组(7例)(P<0.01)。结论SIE患者存在肾小管功能异常,尿RBP含量可以作为评价SLE病情严重程度的指标之一。

Objective To explore the renal tubular changes in patients affected by systemic lupus erythematosus (SLE). Methods Urinary RBP concentration were measured by using ELISA technigue in 33 Patients with SLE, 30 control subjects. Results Urinary RBP concentration in Patients with SLE were significantly higher than those of control subjects (P<0.01). and urinary RBP from 26 active SLE patients was much higher than that of 7 inactive patients (P<0.01). Conclusions The renal tubular function of patients with SLE was non-normal. Urinary RBP concentration could be a marker to evaluate the progression of SLE.