CD15s和p16蛋白在鼻咽癌中的表达及临床意义

Clinical significance of expression of CD15s and p16 in nasopharygeal carcinoma

目的探讨CD15s(唾液酸化,LewisX)和p16基因蛋白表达与鼻咽癌(NPC)转移和预后的关系。方法应用免疫组织化学方法检测分析68例NPC组织中CD15s及p16蛋白表达,结合随访资料分析。结果在NPC中,CD15s抗原和p16阳性表达率分别为42.6%和30.8%。CD15s阳性表达和p16阴性表达与NPC组织学分型、原发病灶分期和淋巴结转移呈正相关(P<0.05),病人5年复发转移率高(P<0.05)、生存率低(P<0.05)。结论CD15s和p16表达与NPC转移和病人生存期密切相关,检测CD15s和p16蛋白的表达可作为判断NPC预后的参考指标。

Objective To investigate the correlation of sialyl CD15s(sialyl Lewis X)antigen and p16 gene expression with metastasis and prognosis of nasopharygeal carcinoma(NPC). Methods Immunohistochemical method was used to detect CD15s antigen and p16 expression in 68 patients with NPC. Results Positive expression rates of CD15s antigen and p16 in NPC were 42.6% and 30.8% respectively. Positive expression of CD15s and negative expression of p16 were positively correlated with the staging of primary NPC,and expression of p16 was positively correlated with primary NPC staging histologic typing, lymph node metastasis.These patients had high recurrence and metastasis rate (P<0.05) and low survival rate(P<0.05) of 5 years. Conclusion These data show that the expression of CD15s antigen and p16 is closely related to NPC metastasis and survival rate.CD15s antigen and p16 may be prognostic indicators of NPC.