胃管注入凝血酶治疗新生儿上消化道出血疗效观察

Effect of thrombin by gastrotube injection on gastrointestinal hemorrhage of newborns

目的观察凝血酶局部给药对新生儿上消化道出血的疗效.方法将新生儿上消化道出血31例分为观察组16例和对照组15例.两组基础治疗相同,观察组加用凝血酶250 U加用0.9%生理盐水5～10 ml经胃管注入,8 h后再用250 U,连用1～2天;对照组加用去甲肾上腺1 ml加用0.9%生理盐水10 ml经胃管注入,8 h后再用1 ml,连用1～2天.结果观察组总有效率93.8%,对照组总有效率53.3%,两组比较差异有显著性意义(P=0.0308).结论胃管注入凝血酶是治疗新生儿上消化道出血简单、方便、安全、有效的方法之一.

Objective To observe the therapeutic effect of thrombin by gastrotube injection on gastrointestinal hemorrhage of the newborns. Methods 31 cases of gastrointestinal hemorrhage were divided into 2 groups including 16 cases of observing group and 15 cases of control group. The basic treatments were the same between the two groups. In the observing group, 250U thrombin dissolved in 5-10 ml of 0.9% NS was injected into the stomach through a stomach tube and repeated the dose following 8 hours and continually for 1~2 days. In the control group, 10 ml of 0.9% NS containing 1ml of noradrenaline was injected into the stomach with the same channel and dosage as above mentioned. Results The efficiency in observing group was 93.8% and that in control group was 53.3%. There was a significant difference between the two groups (P<0.01). Conclusion Thrombin injection through a stomach tube is a simple, convenient, safe and effective treatment for gastrointestinal hemorrhage in newborns. It is worthwhile to use in clinical settings.