ER、PR和ACTH在少年乳腺纤维腺瘤中的表达

Expression of ER,PR and ACTH in Breast Fibroadenoma of Juvenility

目的分析少年乳腺纤维腺瘤的内分泌病因及调查雌激素受体(ER)、孕激素受体(PR)和促肾上腺皮质激素(ACTH)在该肿瘤组织中的表达。方法20例少年乳腺纤维腺瘤光镜下进行回顾性观察并对肿瘤组织行ER、PR和ACTH免疫组织化学染色。结果ER60%(12/20)、PR95%(19/20)和ACTH45%(9/20)在纤维腺瘤中呈阳性表达。结论ER、PR和ACTH可能在少年乳腺纤维腺瘤的发生或病理过程中起着重要的作用。

Objective To analyse the endocrine etiology of breast fibroadenoma in juvenility,and investigate the expression of estrogen receptor(ER), progestogen receptor(PR) and adrenocorticotropic normone(ACTH) in breast fibroadenoma tissue. Methods Twenty cases of breast fibroadenoma were observed retrospectively under the light microscope, and immunohistochemical staining for ER, PR, and ACTH were performed in tumor tissues. Results Positive expression rates for ER, PR and ACTH in fibroadenoma tissue were 60% (12/20), 95%(19/20) and 45%(9/20), respectively. Conclusion ER, PR and ACTH may be the important pathogeny for the occurrence or in pathological process of breast fibroadenoma of juvenility.