新补益汤对记忆获得与血小板聚集的作用

EFFECTS OF XINBUYI TANG ON MEMORY ACQUISITION AND PLATELET AGGREGATION

新补益汤是一补肝肾的复方，经药理实验证明：给小鼠灌服新补益汤２０ｇ／ｋｇ，１次／ｄ，５ｄ。结果发现，在跳台实验中该方能对抗东莨菪碱所致小鼠学习记忆获得障碍，延长错误潜伏期１１７．５±７１．８ｓ，对照组为１３．４±１４．９ｓ（Ｐ＜０．０１），减少错误次数０．８±０．７次，对照组为２．５±１．４次（Ｐ＜０．０１）。该方还能对抗二磷酸腺苷（ＡＤＰ）诱导的大鼠血小板（Ｐｔ）聚集，Ｐｔ聚集率为４１．３５±１．７％，对照组为４９．４７±３．８％（Ｐ＜０．０１）。另外还发现，杞菊地黄丸也能对ＡＤＰ诱导的大鼠Ｐｔ聚集有明显的抑制作用，Ｐｔ聚集率为３５．８６±３．１％，对照组为４９．４７±３．８％（Ｐ＜０．０１）。

Xinbuyi Tang(XBYT)is a prescription with the effects of tonifying the liver and kidney.Pharmacological experiments showed that the decoction of XBYT given orally at a dose of 20g/kg for five successive days,could reduce the impairment of acquisition of memory induced by scopolamine in mice detected with step down test and markedly inhib-ited platelet aggregation induced by ADP in rat.It was also found that Qijudihuang Wan could inhibit the platelet aggregation induced by ADP in rat in addition to reducing the impairment of memory acquisition.