复方厄贝沙坦治疗原发性高血压疗效观察

Effect of irbesartan/hydrochlorothiazide combination on hypertension

目的研究和评价复方厄贝沙坦治疗原发性高血压的疗效和安全性。方法开放研究。选择30名轻中度高血压患者,复方厄贝沙坦(厄贝沙坦150mg/氢氯噻嗪12.5mg)口服,1/d,共8周,观察治疗前后的随测血压和生化指标。结果复方厄贝沙坦能够有效降低轻中度高血压患者的血压(治疗前后收缩压140.5±15.2mmHgvs124.6±8.0mmHg;舒张压93.1±7.3mmHgvs76.2±6.6mmHg,P<0.01),且治疗前后各项生化指标无明显变化。结论复方厄贝沙坦降压效果确切,同时不影响代谢,安全性好。

Objective To study the efficacy of irbesartan/ hydrochlorothiazide combination in treatment of hypertension and their safety. Methods An open study. 30 patients were treated for 8 weeks with irbesartan(150mg)/ hydrochlorothiazide(12.5mg) combination, once daily. Resting blood pressure, biochemical parameters including liver/kidney function, blood electrolyte, and urine analysis were evaluated before and after the treatment. Results Resting blood pressure were significantly reduced after treatment (Before and after treatmnet, systolic pressure140.5±15.2mmHg vs 124.6±8.0mmHg;diastolic pressure 93.1±7.3mmHg vs 76.2±6.6mmHg,P<0.01). No changes of biochemical parameters were observed. Conclusions Irbesartan/ hydrochlorothiazide combination can effectively and safely reduce the resting blood pressure.