克癌7851与喃呋啶联合应用的抗癌效果

ANTICANCER EFFECTS OF AC 7851 COMBINED WITH FTORAFUR IN MICE

将克癌７８５１（３２０ｍｇ／ｋｇ）与喃呋啶（６０ｍｇ／ｋｇ）联合应用，观察其对小鼠肝癌（ＨｅｎＡ）的抗癌作用。结果表明：联合组的平均瘤重明显小于对照组，抑瘤率为５８．９％～６８．７％，平均存活期亦明显延长，观察４６ｄ联合组存活率为５／１０～７／９，癌细胞ＤＮＡ含量明显下降。结果提示：小剂量喃呋啶与克癌７８５１伍用有明显的协同抑瘤效果。

AC 7851(320 mg/kg)was used in combination with small dose of ftoratur(FT 60 mg/kg).Results showed that inhibitory rate(58.9%～68.7%)in the combined theat-ment group was higher than that of control group.The number of survived mice was 5/10～7/9 in combined treatment group.The DNA content in combined treatment group was lower than that of control group.The results indicated that AC 7851 combined with small dose of FT not only had considerable inhibitory effect on tumors,but also reduced the side effects of chemotherapy.