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大鼠结肠癌淋巴转移时树突状细胞的表达 被引量：1

Expression of dendritic cells in the metastatic lymph nodes of colon cancer in rats
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摘要 目的研究大鼠结肠癌淋巴转移时树突状细胞的表达与淋巴转移的关系。方法用S100蛋白质抗体对12例大鼠结肠癌动物模型的肠周淋巴结转移灶和8例正常大鼠肠周淋巴结进行免疫组化染色。结果定量分析显示,肠周淋巴结转移灶中S100蛋白阳性树突状细胞(DCs)明显低于正常大鼠肠周淋巴结树突状细胞(DCs)(P<0.01)。结论提示DCs在防止肿瘤转移方面有重要意义。 Objective To study the relationship between dendritic cells(DCs ) distribution in the metastatic lymph nodes of colon cancer in rats and the lymphatic metastasis.Methods In this study,DCs were quantitatively assayed by immunohistochemical method against S 100 protein antibody in 12 cases of lymphatic metastasis of colon cancer in rats,and 8 cases of normal rats.Results The numbers of DCs in normal group was more than those in metastasis group( P <0.01).Conclusion The distribution of DCs has relation with the metastasis of colon cancer,and it shows great significance in preventing the metastasis of colon cancer.
作者 董广为 杜智敏 杨宝峰
机构地区 哈尔滨医科大学第二临床医学院临床药理学研究所 哈尔滨医科大学药理学教研室
出处 《哈尔滨医科大学学报》 CAS 北大核心 2005年第3期224-225,共2页 Journal of Harbin Medical University
基金 黑龙江省自然科学基金资助项目(D0230)
关键词 结肠癌 淋巴转移 S-100蛋白质 树突状细胞 大鼠 colon cancer lymphatic metastasis S 100 protein dendritic cells rat
分类号 R-332 [医药卫生] R735.35 [医药卫生—肿瘤]
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参考文献6

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同被引文献8

  • 1黎剑,詹文华,蔡世荣,Bembenek,A,Schlag,PM.乳腺癌淋巴结微小转移状态下前哨与非前哨淋巴结免疫细胞的改变[J].中华实验外科杂志,2007,24(1):7-8. 被引量：4
  • 2Takeuchi H, Kitajima M, Kitagawa Y. Sentinel lymph node as a target of molecular diagnosis of lymphatic micrometastasis and local immunoresponse to malignant cells. Cancer Sci ,2008,99:441-450.
  • 3Li X, Takahashi Y, Sakamoto K, et al. Expression of dendritic cell phenotypic antigens in cervical lymph nodes of patients with hypopharyngeal and laryngeal carcinoma. J Laryngol Oto1,2009,123:5-10.
  • 4Grabau D, Ryden L, Ferno M, et al. Analysis of sentinel node biopsy-a single-institution experience supporting the use of serial sectioning and immunohistochemistry for detection of micrometastases by comparing four different histopathological laboratory protocols. Histopathology, 2011,59 : 129-138.
  • 5Iwamota M, Shinohara H, Miyamoto A, et al. Prognostic value of tumorinfiltrating dendritic ceils expressing CD83 in human breast carcinomas. Int J Cancer, 2003,104 : 92 -97.
  • 6Prechtel AT, Steinkasserer A. CD83 :an update on functions and prospeets of the maturation marker of dendritic cells. Arch Dermatol Res, 2007,299:59-69.
  • 7Kohrt HE, Nouri N, Nowels K, et al. Profile of immune cells in axitlary lymph nodes predicts disease-free survival in breast cancer. PLos Med ,2005,2 : e284.
  • 8朱玉兰,钱科卿,秦建伟,陈小平,时宏珍,赖娅娜,唐金海.乳腺癌细胞抗原负载的自体树突状细胞体内诱导特异性T细胞应答[J].中华实验外科杂志,2010,27(6):708-710. 被引量：7

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哈尔滨医科大学学报
2005年 第3期

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