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阿司匹林抵抗与尿11-脱氢-血栓素B_2的相关性研究 被引量：2

Correlation study of aspirin resistance and urinary 11-dehydro thromboxane B_2
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摘要 目的探讨服用阿司匹林后,因个体差异导致尿11脱氢血栓素B2(11DTB2)含量的变化。方法109例心脑血管疾病患者服用阿司匹林(100mg/d)至少7天以上后,用二磷酸腺苷(ADP)和花生四烯酸(AA)作诱导剂测定血小板聚集功能,并测定其11DTB2的含量。结果阿司匹林抵抗者11DTB2同阿司匹林敏感者比较有明显差异。结论尿11DTB2同阿司匹林抵抗有一定的相关性。 Objective To explore changes of urinary 11 dehydro TXB 2 level of individuals after taking aspirin.Methods One hundred and nine patients with stable cardiovascular and cerebrovascular diseases took aspirin (100mg/d for ≥7 days).We detected platelet aggregation function using adenosine disphosphste (ADP) and arachidonic acid (AA) and measured urinary 11 dehydro TXB 2 levels.Results 11 dehydro TXB 2 levels of patients who were aspirin resistant was significantly higher than that of aspirin sensitive patients.Conclusion Urinary 11 dehydro TXB 2 level can reflect individual difference of aspirin effect.
作者 金英玉 辛晓敏 张云平 关秀茹 李洁
机构地区 哈尔滨医科大学第一临床医学院实验诊断教研室
出处 《哈尔滨医科大学学报》 CAS 北大核心 2005年第3期277-278,281,共3页 Journal of Harbin Medical University
关键词 阿司匹林抵抗 血小板聚集 尿11-脱氢-血栓素B2 aspirin resistance platelet aggregation urinary 11 dehydro thromboxaneB 2
分类号 R541.4 [医药卫生—心血管疾病] R743 [医药卫生—神经病学与精神病学]
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参考文献6

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同被引文献19

  • 1陈世德,伍伟锋.阿司匹林抵抗的研究进展[J].医学综述,2005,11(6):529-531. 被引量：5
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哈尔滨医科大学学报
2005年 第3期

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