帕金森病记忆障碍的脑电活动研究

Study on brain electrical activity in patients with memorial impairment Parkinson disease

目的:通过比较帕金森病(PD)患者记忆障碍组与健康老年人的脑电图特点,探讨帕金森病记忆障碍与脑电活动的关系。方法:选择50例PD记忆障碍患者为试验组进行脑电图(EEG)检查,同时取35例健康老年人为对照组进行记忆测定和EEG检查。结果:试验组EEG异常率明显高于对照组(P<0.01);试验组EEG波低波幅者、低波率者、低指数者及有泛化者均显著高于对照组(P<0.05或0.01);试验组异常EEG快波(β)及慢波(θ、δ)出现率均高于对照组,但以θ、δ波为著(P<0.05)。结论:记忆测定和EEG检查对判断PD的认知功能障碍有实用价值。

Objective: To compare the changes of electroencephalogram(EEG) in patients with memorial impairment Parkinson disease (experiment group) and normal senile people (control group). To explore the relationship between brain electrical activity and Parkinson′s memorial impairment.Method:The memorial performance were tested with clinical Memorial Test in 140 patients with Parkinson disease and 35 control persons. EEG were performed in 50 patients with memorial impairment PD and control group.Result:The abnormality rate of EEGs was significantly higher in the experiment group than the control group(P<0.01); The low wave amplitude,low wave frequency,low indiex or generalized α wave of EEG were significantly higher in experiment group than in the control group(P<0.01 or 0.05). The detection rate of θ wave and δ wave were significantly higher in experiment group than in the control group(P<0.05). Conclusion:The memorial performance and EEG are valuable tools to evaluate cognitive function impairment in PD.