血小板去除术合用药物序贯疗法治疗原发性血小板增多症

The treatment of essential thrombocythemia with the combination of platelet separation and hydroxyurea/IFN- alpha

目的观察血小板去除术后,序贯应用羟基脲、α-干扰素治疗原发性血小板增多症的疗效。方法应用血细胞分离机CS-3000Plus去除血小板,随后应用羟基脲、α-干扰素等药物治疗。结果原发性血小板增多症患者行血小板去除术,能迅速降低血小板,缓解症状。应用羟基脲进一步控制血小板生成,巩固疗效,并用α-干扰素维持治疗。结论血小板去除术配合应用羟基脲、α-干扰素治疗原发性血小板增多症,能迅速降低血小板,减少并发症发生并能巩固疗效。

Objective To study the efficacy of platelet separation plus hydroxyurea/IFN- alpha in turn on essential thrombocythemia. Methods 11 patients with essential thrombocythemia were treated with platelet separation plus hydroxyurea and IFN- alpha. Results The platelet count decreased significantly after the platelet separation and keep in stable condition after the HU and IFN- alpha therapy. Conclusions The combination of platelet separation and HU/IFN is an effective way to treat the patients with essential thrombocythemia.