多发性骨髓瘤患者血清中VEGF含量与疾病严重程度的关系

The relationship of angiogenic cytokines vascular endoehelial growth factor with multipal myeloma between clinical significances

目的研究血管内皮生长因子(VEGF)与多发性骨髓瘤(MM)的关系,探索其临床意义。方法用双抗体夹心酶联免疫吸附测定法,检测37例MM患者不同时期的VEGF血清浓度,观察其与MM临床分期、肿瘤量分级、治疗效果和骨损评分的关系。结果MM患者血清中的VEGF较正常人明显升高;MM患者Ⅰ期、Ⅱ期的VEGF血清水平显著低于Ⅲ期,而Ⅰ、Ⅱ期之间差异无统计学意义;不同肿瘤量分级的MM患者间血清总VEGF含量差异有显著性;MM治疗有效者,血清VEGF水平比治疗前明显降低,而治疗无效者,其血清VEGF水平与治疗前比较差异无统计学意义;不同骨损评分组间VEGF含量差异无统计学意义。结论血管生成调控因子VEGF血清水平与MM的疾病严重程度有关。

Objective To explore the relationship of angiogenic cytokines vascular endothelial growth factor(VEGF) with multiple myeloma (MM) and to explore clinical significances. Methods The serum levels of VEGF were detected by enzyme- linked immunosobant assays technique in 37 patients with MM, compared with 18 controls(healthy volunteers). The associations between the cytokines serum levels with MM stages (Ⅰ-Ⅲ) and with MM curative effect were observed. Results Pretreatment MM had significantly higher VEGF serum levels than controls. Pretreatment serum levels of VEGF were significantly lower in stage Ⅰ,Ⅱthan in stage Ⅲ MM, and between stage Ⅰ and stage Ⅱ there was no significantly difference. There are significantly difference between different the tumor load. In the patients responding to chemotherapy a significantly decrease in VEGF serum levels occurred, while in the patients who did not achieve a remission, there was no significant decrease in them. The values of VEGF showed no difference according to bone lesion scores. Conclusions The serum levels of angiogenic factors VEGF are related to the severity of MM.