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同源盒基因HoxA_(10)与白血病 被引量：1

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摘要 HoxA10基因是调控造血的转录因子,具有髓系特异性,其表达失衡与白血病的发生有关。HoxA10基因在造血细胞发育过程中起双重作用,对早期细胞增生有增效作用,表达下调允许细胞向髓系分化。HoxA10基因主要表达在髓系白血病,少有淋系表达,与HoxA9、Pbx1、Meisl等共同影响白血病的进程。有临床监测和增强体外干细胞扩增的应用前景。
作者 黄颖 李维佳
机构地区 昆明医学院第一附属医院血液科
出处 《白血病．淋巴瘤》 CAS 2005年第3期178-180,共3页 Journal of Leukemia & Lymphoma
关键词 同源盒基因 HOXA10基因 髓系白血病 转录因子 表达失衡 双重作用 发育过程 造血细胞 增效作用 细胞增生 表达下调 细胞扩增 临床监测 特异性
分类号 R733.7 [医药卫生—肿瘤]
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参考文献20

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二级参考文献11

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白血病．淋巴瘤
2005年 第3期

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