膜窖的区室化调节功能及药物设计策略探讨

Compartmentalized Regulation in Caveolae and Implications for Drug Design Strategies

膜窖是脂筏的一种特殊类型,在哺乳动物的内皮细胞、脂肪细胞及平滑肌细胞质膜上分布尤为丰富。近年来对于膜窖的区室化调节与生理功能及其应用于药物设计方面的研究日益受到关注,如利用基因剔除、荧光共振能量转移等技术研究窖蛋白功能及膜窖内信号蛋白的互相作用,从而为新型药物的设计打下理论基础。

As specialized lipid rafts, caveolae are present on many types of mammalian cells, particularly on endothelial cells, adipocytes and smooth muscle cells. Recent studies mostly focus on compartmentalized regulation and physiological role of caveolae with the aim to develop novel drug delivery strategies. New techniques including gene knockout and fluorescence resonance energy transfer provide valuable tools for elucidating functions of caveolin as well as investigating signaling protein interactions in caveolae, which may benefit for drug design.