茶儿茶素抑制肿瘤血管生成的作用

Inhibitory Effects of Tea Catechins on Tumor Angiogenesis

对近几年茶儿茶素抑制肿瘤血管生成的研究进展进行了综述。从抑制血管内皮细胞生长、抑制细胞黏附分子表达和抑制基底膜降解三个部分讨论了其抗肿瘤血管生成的机制,并对儿茶素研究存在的问题和儿茶素开发前景进行了探讨。

The progress showed in the recent investigation of antiangiogenic mechanisms of catechins was reviewed in this paper. The mechanisms of angiogenic activity were discussed from the following three aspects: inhibition of the vascular endothelial cell proliferation, inhibition of cell adhesion molecule expression and suppres- sion of basement membrance degradation, in the meantime, the investigational problems in existence and the devel- opment of catechins in the future were tentatively discussed as well.