血清一氧化氮水平在甲亢时的变化

Study on the Change of Nitric Oxide in the Serum of the Patients with Hyperthyroidism

目的探讨甲亢患者血清一氧化氮(NO)水平的变化及其临床意义。方法用放射免疫分析法和分光光度法分别测定了52例甲亢患者血清中的甲状腺激素和NO的水平。结果甲亢病人治疗前、后NO水平分别为92.4±18.3μmol/L和74.8±15.2μmol/L,均明显高于对照组的56.6±10.2μmol/L,甲亢治疗前NO与甲状腺激素水平呈明显正相关(P<0.05),与促甲状腺激素(TSH)呈显著负相关(r=-0.56,P<0.05),治疗后随着甲状腺功能的改善NO下降较为显著(P<0.05),但仍高于对照组。结论甲状腺激素可调控NO的代谢,治疗适当加用抗氧化剂,对预防并发症的发生具有重要意义。

Objective To probe into the changes of serum nitric oxide (NO) in hyperthyroidism and their clinical significance. Methods By radioimmunoassay (RIA) and spectrophotometry, the levels of thyroid hormone and NO were tested on 52 hyperthyroids before and after treatment. Results The hyperthyroids' NO levels before and after treatment were 92.4±18.3μmol/L and 74.8±15.2μmol/L respectively. They were greatly different (P<0.01), and obviously higher than that of the control group (56.6±10.2μmol/L, P<0.01). Before treatment, NO showed obvious positive correlation with thyroid hormone (P<0.05), and very marked negative correlation with thyrotropin(TSH)(P<0.05).Conclusion Thyroid hormone can adjust and control NO metabolism, which has significant importance to prevent the diseases of cardiac and cerebral vessels, if proper antioxidizer is added as therapy.