BN大鼠脉络膜新生血管动物模型的制作

CNV ANIMAL MODEL OF BN RAT

目的:脉络膜新生血管(CNV)是许多眼病致盲原因,目前无理想治疗方法,深入研究其发病机理及探索其治疗新方法成为必要。制作CNV动物模型是该研究的基础。方法:本研究拟用氩激光诱导BN大鼠CNV动物模型,并用组织病理切片及眼底荧光血管造影进行观察。结果:光凝后7d新生血管形成,21d达高峰,光凝区出现圆盘状的荧光素渗漏。结论:氩激光光凝可以成功制作BN大鼠CNV动物模型,为CNV防治的研究奠定了基础。

Purpose:choroidal neovasculariztion(CNV) is the cause of many eye diseases, there is no ideal treatment method. It is necessary to investigate its developing machenism and new treatment method. CNV animal model is its foundation.Method: CNV animal model was induced by Ya laser coagulation in BN rat ,and was observed by histopathology and FFA. Result: Neovascular was fomed 7d after laser coagulation and reach the peach at 21d. It has discal permeation. Conclusion: It is demonstrated that CNV can be induced by Ya laser coagulation in BN rat and provide the foundation for the prohibition and treatment of CNV.