益母定痛颗粒对动物痛经模型的治疗作用

Curative Effects of Yimudingtong Granules on Dysmenorrhea Models in Animals

目的观察益母定痛颗粒对动物痛经模型的治疗作用。方法分别灌胃给予小鼠、大鼠,经十二指肠给予家兔。结果益母定痛颗粒对己烯雌酚和缩宫素联用引起的小鼠痛经模型以及己烯雌酚和前列腺素(PGF2α)联用引起的大鼠痛经模型有明显的治疗作用,显著降低动物扭体反应次数;对家兔在体子宫正常收缩的幅度、频率和活动力均有明显抑制作用,对缩宫素引起的家兔在体子宫收缩的幅度有降低趋势,对其收缩的频率和活动力有明显降低。结论益母定痛颗粒对离体和在体痛经动物模型有较好的治疗作用。

Objective To observe the therapy effects of Yimudingtong granules on dysmenorrhea models in animals. Methods Yimudingtong granules was administered to mice and rat through stomach and rabbits through duodenum. Results Yimudingtong granules had markedly therapy effects on the dysmenorrhea models made in mice and rats by diethylstilbestrol and oxytocin or PGF (2α). It could also markedly decrease the amplitude, frequency and activity of rabbit uterus in normal and stimulated by oxytocin in vivo. Conclusions Yimudingtong granules had a good curative effect on animal dysmenorrhea models.