恩丹西酮联合地塞米松对腹腔镜手术后恶心呕吐的影响

Influence of ondansetron combined with dexamethasone on post laparoscopic surgery nausea and vomiting

目的观察恩丹西酮联合地塞米松对腹腔镜手术后恶心呕吐的影响。方法随机将100例在全麻下择期行腹腔镜手术的患者分为5组:A组,生理盐水对照组;B组,恩丹西酮组;C组,地塞米松组;D组,氟哌利多组;E组,恩丹西酮+地塞米松组。观察术后24h内病人恶心呕吐发生的情况及不良反应。结果A组恶心呕吐发生率为70%,明显高于B组(30%)、C组(30%)、D组(20%)和E组(15%),P<0.05;E组与B组和C组比较,P<0.05;与D组比较,P>0.05。但D组不良反应较多。结论恩丹西酮联合地塞米松静脉应用对降低腹腔镜手术后恶心呕吐的发生率有确切效果。

Objective To investigate the influence of ondansetron combined with dexamethasone on post laparoscopic surgery nausea and vomiting. Methods With double blind method, 100 patients scheduled for laparoscopic surgery under general anesthesia were randomly divided into five groups: Group A ( control, with brine ), Group B ( with ondansetron ), Group C ( with dexamethasone ). Group D (with droperidol) and Group E ( with ondansetron combined dexamethasone ). Nausea and vomiting episodes were recorded for 24h after surgery. Results The incidence of nausea and vomiting in group A(70%) was higher than that in group B(30%) ?group C(30%)?group D(20%)and group E(15%)(P<0.05). The incidence in Group E(15%) was lower than that in group B and in group C(P<0.05), and was approximate to that in group D(20%) (P>0.05). But more side effects were found in group D. Conclusions Ondansetron combined with dexamethasone could reduce the incidence of post laparoscopic surgery nausea and vomiting.