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骨质疏松相关基因研究进展 被引量：4

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摘要 骨质疏松症(OP)是多种因素导致的复杂疾病,它的发生与峰值骨量高低和骨量丢失速度密切相关,而遗传与环境因素参与了峰值骨量的达到、维持以及骨量丢失的调节.研究证实,遗传因素可解释60%～80%骨密度(BMD)的变化.近年来,对导致OP相关基因的研究成为热点,目前已对约60种与骨代谢有关的基因及其多态性与骨质疏松表型的关系进行了研究.这些候选基因中,VDR、ER、COLIA1、白介素家族(IL-lra,6,11)、胰岛素样生长因子IGF-1、骨钙素、降钙素及其受体、TNFα等基因的研究报道较多,本文对另几个候选基因的研究现状作一综述.
作者 杨妤欣 陈隽
机构地区 重庆医科大学附属第二临床学院内分泌科
出处 《中国骨质疏松杂志》 CAS CSCD 2005年第2期263-265,268,共4页 Chinese Journal of Osteoporosis
关键词 基因研究进展 骨量丢失 峰值骨量 骨质疏松症 复杂疾病 环境因素 遗传因素 相关基因 骨密度 多态性 骨代谢
分类号 R725.622.5 [医药卫生—儿科] R681 [医药卫生—骨科学]
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参考文献24

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二级参考文献11

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共引文献18

同被引文献73

引证文献4

二级引证文献118

中国骨质疏松杂志
2005年 第2期

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