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遗传决定骨量 被引量：5

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摘要 骨质疏松是以骨量减少,骨微结构改变,骨脆性增加易发生骨折为特征的疾病.骨量主要受两方面影响:获得的峰值骨量和随年龄增长发生的骨丢失.
作者 梁颖 刘忠厚
机构地区 首都医科大学附属北京妇产医院妇幼保健院放射科
出处 《中国骨质疏松杂志》 CAS CSCD 2005年第2期269-272,258,共5页 Chinese Journal of Osteoporosis
关键词 单卵双生子间 骨质疏松 峰值骨量 骨量减少 结构改变 遗传因素 澳大利亚 相关系数 骨丢失 BMD
分类号 R699.2 [医药卫生—泌尿科学] R681 [医药卫生—骨科学]
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参考文献19

  • 1Krall EA, Dawson-Hugher B. Heritable and life style de terminants of bone mineral density. J Bone Miner Res, 1993, 8: 19.
  • 2Pocock NA, Eisman JA, Hopper JL, et al. Genetic determinants of bone mass in adults. J Clin Invest, 1987, 80:706-710.
  • 3Kely PJ, Nguyen T, Hopper J, et al. Changes in axial bone density with age: a twin study. J Bone Miner RES, 1993, 8:11-17.
  • 4Hustmyer FG, Peacock M, Hui S, et al. Bone ineral density in relation to polymorphismt the vitamin D receptor genelocus. J Clin Inest, 1994, 94: 2130-2134.
  • 5Gennari L, Becherini L, Falchetti A, et al, Genetics of osteoprosis: role of steroid hormone receptor gene polymorphisms. Journal of Steroid Biochemary & Molecular Biology,2002, 81: 1-24.
  • 6陈金标,秦林林.骨质疏松症与遗传[J].中国骨质疏松杂志,2000,6(1):89-92. 被引量：7
  • 7Gennar L, Becher L, Mansani R, et al. Fok I polymorphism attranslation in itiation site of the vitamin D receptor genepredicts bone mineral density and vertebral fractures in postmenopausal Italian women. J Bone Miner Res, 1999, 14:1379-1386.
  • 8黄琪仁,章振林,秦跃娟,何进卫,陆敬辉,周琦,胡云秋,李淼,刘玉娟.维生素D受体基因ApaⅠ多态性与男性骨量的关系[J].中国医学科学院学报,2003,25(3):254-257. 被引量：11
  • 9Kung AWC, Teung SSC, Lau KS, et al. Vitamin D receptor gene polymorphisms and peak bone masssin Southern Chinese women. Bone, 1998, 22: 389-393.
  • 10Hansen TS, Abrahamsen B, Henriksen FL, et al. Vitamin D reeptor alleles do not predict bone mineral density or bone loss in Danish perimenopausal women. Bone, 1998, 22:571-575.

二级参考文献34

  • 1闫丽娅,王晓红,张卉,侯菊倩,韩延柏.VDR基因型分布及其与骨矿含量的关系[J].中国骨质疏松杂志,1997,3(2):19-21. 被引量：11
  • 2Harris M, Nguyen TV, Howard GM, et al. Genetic and environmental correlations between bone formation and bone mineral density: a twin study. Bone, 1998, 22:141-145.
  • 3Pocock NA, Eisman JA, Hopper JL, et al. Genetic determinants of bone mass in adults: a twin study. J Clin Invest, 1987, 80:706-710.
  • 4Ralston SH. Genetic control of susceptibility to osteoporosis.J Clin Enderinol Metab, 2002, 87:2460-2466.
  • 5Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor gene alleles. Nature,1994, 367:284-287.
  • 6Riggs BL, Nguyen TV, Melton J, et al. The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Mineral Res, 1995, 10:991-996.
  • 7Zhao X J, Zhou XY, Men XW, et al. Pdymorphisms of vitamin D receptor gene and its association with bone mineral density and osteocalcin in Chinese. Chin Med J,1997, 110:366-371.
  • 8Lan EMC, Young RP, Ho SCH, et al. Vitamin D receptor gene polymorphisms and bone mineral density in eldedy Chinese men and women in Hong Kong. Osteoprosis Int,1999, 10:226-230.
  • 9Bell NH, Morrison NA, Nguyen TV, et al. Aim I polymorphisms of the vitamin D receptor predict bone density of the spine and not racial difference in bone density in young men. J Lab Clin Med, 2001, 1.37:133-140.
  • 10Ensnld K, Stone K, Cauley JA, et al. Vitamin D receptor gene polymorphisms and the risk of fractures in older women. J Bone Miner Res, 1999, 14:1637-1645.

共引文献25

同被引文献74

引证文献5

二级引证文献18

中国骨质疏松杂志
2005年 第2期

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