半夏合剂对模型动物气道分泌物的清除作用研究

Study on the Cleaning Action of Rhizoma Pinelliae Mixture on Trachea Secretions

目的:探讨半夏合剂对模型动物气道分泌物的清除作用。方法:将大鼠随机分为半夏合剂高、低剂量组及对照组,采用气管切开造口术建模,腹腔注射酚红后观察各组大鼠酚红排泌量;观察半夏合剂给药前、后蟾蜍口腔粘膜上皮纤毛运动使软木屑移动同等距离所用的时间。结果:与对照组比较,半夏合剂气管酚红排泌量显著增加(P<0 .01) ;与给药前比较,给药后蟾蜍口腔粘膜上皮纤毛运动使软木屑移动同等距离所用的时间显著缩短(P<0 .01)。结论:半夏合剂对实验模型大鼠及蟾蜍气道分泌物的清除具有促进作用。

OBJECTIVE:To explore the cleaning action of rhizoma pinelliae mi xture(RPM)on trachea secretions of the model animals.METHODS:The rats were divided randomly into high and low dose of RPM group and the control group;Then the secretion level of phenol red in each group was observed after the forming of models by tracheostomy and intraperitonal injection with phenol red;The respective time that spent on moving cork wood filings to a same distance by oral mucosa ep ˉithelium ciliary movement of toad both before and after medication were observed.RESULTS:The secretion level of phenol red in RPM group increased significantly compared with the control group(P<0.01);the time spent on moving cork wood filings to the same distance by ciliary movement on the mucous membrane of oral cavity of toad was significantly shortened after medication compared with before medication(P<0.01).CONCLUSION:RPM can promote the excretion of trachea excreta of both the experimental model rats and the toad.