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趋化因子RANTES在RSV感染中的表达及作用 被引量：1

The Expression and Effects of RANTES in RSV Infections
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摘要 呼吸道合胞病毒(RSV)是婴幼儿急性下呼吸道感染最常见的病原体,可引起毛细支气管炎、肺炎等严重疾病。RSV引起的严重下呼吸道感染时气道有大量的炎性细胞募集,其机制可能与CC趋化因子RANTES的释放有关。RSV感染可募集和激活多种细胞,包括嗜酸性粒细胞、嗜碱性粒细胞、单核细胞、淋巴细胞,同时也激活气道上皮细胞、平滑肌细胞及肺泡巨噬细胞,通过核因子 κB的活化引起RANTESmRNA和蛋白水平升高。RANTES水平升高进一步引起炎性细胞趋化、募集到气道黏膜而加重炎症,可能是导致RSV感染后气道高反应性和哮喘发生的重要因素。
作者 陈小芳 楼永良 董琳 吕建新
机构地区 温州医学院附属育英儿童医院 温州医学院检验学院
出处 《国外医学（儿科学分册）》 2005年第3期162-164,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 趋化因子 CC RANTES 呼吸道合胞体病毒感染
分类号 R725.6 [医药卫生—儿科]
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参考文献20

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同被引文献10

  • 1Reijonen TM, Kotaniemi-Syrjanen A, Korhonen K, Korppi M.Predictors of asthma three years after hospital admission for wheezing in infancy[J]. Pediatrics, 2000, 106(6) :1406-1412.
  • 2Kim HH, Lee MH, Lee JS. Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis [J]. J Korean Med Sci, 2007, 22( 1 ) :37-42.
  • 3Lai CC, Tai HY, Shen HD, Chung WT, Chung RL,Tang RB. Elevated levels of soluble adhesion molecules in sera of patients with acute bronchiolitis [ J ]. J Microbiol hnmunol Infect, 2004, 37 (3) :153-156.
  • 4Arnold R, K-nig W. Respiratory syncytial virus infection of human lung endothelial cells enhances selectively intercellular adhesion molecule-1 expression [ J ]. J Immunol, 2005, 174 ( 3 ) : 7359- 7367.
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  • 6Tian M, Liu F, Wen GY, Shi SY, Chen RH, Zhao DY. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China[J]. Eur J Pediatr, 2009, 168(8):963-967.
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  • 8董琳,陈小芳,周晓聪,林剑,李锦燕,张伟.RSV毛细支气管炎RANTES MIP-1αIL-8水平变化及相关性研究[J].浙江临床医学,2007,9(10):1307-1308. 被引量：8
  • 9陈叶,肖启亮,胡晓燕,邓莉莉.儿童毛细支气管炎血清sICAM-1和Eotaxin水平测定的临床意义[J].南华大学学报（医学版）,2008,36(1):75-78. 被引量：3
  • 10朱萍,邹丽萍.毛细支气管炎患儿外周血单个核细胞CD40/CD40L的表达[J].中国当代儿科杂志,2009,11(5):354-356. 被引量：4

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二级引证文献11

国外医学（儿科学分册）
2005年 第3期

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