丙型肝炎病毒与甲乙型肝炎病毒重叠感染的研究

Superinfection of Hepatitis C Virus with Hepatitis A and B Virus

对485例病毒性肝炎患者进行了抗HCV、抗HAV-IgM、HBV-M检测.各型病毒性肝炎患者中抗HCV阳性率15.05％,慢性肝炎、肝硬变和重型肝炎阳性率高于急性肝炎;抗HCV阳性者中,27.40％有输血或血浆史;57.53％HBV-M阳性,其中HBsAg阳性占54.76％,抗HBc阳性达88.10％;既往有HBV感染者占33.33％.HBV与HCV重叠感染中慢性肝炎占58.06％,IAV与HCV重叠感染以急性肝炎多见(94.44％),HCV与甲乙型肝炎病毒三重感染可加速肝炎重症化的进程。

Anti-HCV, anti-HAV-IgM, HBV-M were determined in 485 patients with viral hepatitis. The pasitive rate of anti-HCV in all of the patients with viral hepatitis were 15.05% , in chronic hepatitis, hepatocirrhosis and fulminant hepatic failure were higher. The results showed that HCV infection acts on the process of chronicity, seriousness in hepatitis and oc-curing on hepalocirrhosis. 27. 40% patients with positive anti-HCV were infused whole blood or blood plasma. 57.53% were positive HBV-M including 54.76% positive HBsAg and 88. 1% positive anti-HBc. 33.33% infected HBV in past. Superinfection of HBV and HCV were chronic hepatitis. 94. 44% Superinfection of A, B and C virus caused fulminant hepatic failure, the cooperation may speed up the process of developing fulminant hepatic failure.