转基因植物疫苗研究进展

Research progress of transgenic plant-derived vaccines

众多研究表明,病毒的抗原决定簇及细菌毒素亚单位均能在转基因植物中成功表达,并保持良好的免疫原性。与现有的疫苗生产体系相比,植物生产疫苗具有安全、经济、稳定、高效等优势。本文概述了利用不同受体植物生产疫苗的研究现状、免疫原性评价及免疫原基因的优化表达策略。

Numerous studies have shown that viral epitopes and subunits of bacterial toxins can be expressed and correctly processed in transgenic plants. The recombinant proteins induce immune responses and have several (benefits) over current vaccine technologies, including increased safety, economy, stability and efficacy. Examples of different types of expression systems producing a variety of vaccine candidates are illustrated, as well as their immunogenicity evaluation. This review also includes strategies on optimal expression of immunogenic genes in transgenic plants vaccine and its application prospects.