表皮生长因子受体、C-erbB_2和细胞增殖核抗原联合检测判断乳腺癌的预后

Expression and significance of EGFR,C-erbB_2 and PCNA in primary breast carcinoma tissues

目的研究乳腺癌组织表皮生长因子受体(EGFR)、癌基因CerbB2和细胞增殖核抗原(PCNA)变化规律,探讨EGFR、CerbB2和PCNA预测乳腺癌复发的价值。方法应用免疫组化检测57例良、恶性乳腺病变组织中EGFR、CerbB2、PCNA的表达,并比较其阳性表达率和程度的差异。结果复发乳腺癌和无复发乳腺癌组织EGFR、CerbB2、PCNA阳性表达率均较乳腺纤维腺瘤组织高,复发乳腺癌PCNA,CerbB2阳性表达程度高于无复发乳腺癌。结论EGFR、CerbB2、PCNA可反映癌组织细胞增殖活跃,PCNA、CerbB2过表达在预测乳腺癌复发和选择治疗方式具有一定价值。

Objective To study the expression of EGFR,C-erbB_2 and PCNA in primary breast carcinoma tissues and the value of them in predicting the recurrence of primary breast carcinoma.Methods The expression of EGFR,C-erbB_2,PCNA in 57 benign and malignant breast paraffin-embedded specimens was detected by using immunohistochemical assay and compared.Results The positive rate of EGFR,C-erbB_2,PCNA was increased significantly in malignant breast tissues as compared with benign breast tissues.The positive intensity of PCNA,C-erbB_2 was increased significantly in tissues of recurrent breast carcinoma as compared with tissues of no recurrent breast carcinoma.Conclusion The expression of EGFR,C-erbB_2 and PCNA may indicate the active proliferation activity of carcinoma cells.The detection of the overexpression of PCNA and C-erbB_2 can predict the recurrence of breast carcinoma and is beneficial to the choose of the treatments.